Mapping the
Whole Human Brain at
Cellular Resolution
The Sudha Gopalakrishnan Brain Centre (SGBC) at the Indian Institute of Technology Madras is a pioneering research centre dedicated to high-resolution imaging and 3D reconstruction of the whole human brain. The centre has developed a state-of-the-art, experimental and computational platform for high-resolution tera-pixel imaging of ex vivo human brains. This centre was set up to drive brain research through advanced integrated neuroanatomy with the interface between the Neuroscience and Engineering disciplines. At SGBC, we study the whole human brain through multimodal imaging at cellular resolution, from structural MRI to histology.
Our Research Areas
Our research is focused on mapping the human brain across health and disease by integrating structural, molecular, and imaging data. Using a combination of histopathology, molecular techniques, and structural MRI, supported by advanced bioinformatics and neuroinformatics, we aim to characterise changes in brain architecture across development, injury, aging, and disease. Together, these approaches enable integrated analysis and interpretation of complex human brain data.
Neurodevelopment
Stroke
Developmental Disorders
Aging and Neurodegeneration
Neuroinfections
The Three Pillars
Histopathology
Explore our high-resolution, multimodal histology platform, featuring a range of specialized staining techniques to study the human brain at cellular resolution. These staining methods provide detailed insight into tissue architecture, neuronal organization, and white- and gray-matter structures across adult and fetal brains.
Computational
Discover our computational backbone, spanning from image-processing pipelines to large-scale data analytics. Learn how we handle massive-scale neuroimaging datasets to advance global neuroscience research.
Technology & Engineering
Delve into the engineering innovation driving SGBC from cryomacrotome imaging systems and custom brain slicing platforms to scalable computer clusters. This unit highlights our in-built hardware/software solutions, which enable high-throughput brain histology.
Our Publications
At the Sudha Gopalakrishnan Brain Centre (SGBC), our research findings are regularly disseminated through peer-reviewed journals, book chapters, and conference proceedings. These publications reflect the centre's commitment to advancing fundamental and translational neuroscience. By sharing our work with the global scientific community, we aim to foster collaboration, drive innovation, and contribute to a deeper understanding of the brain and its disorders.
News & Events
Genetic, Cellular and Intercellular Principles of Human Brain Development
A lecture by Dr. Tomasz Nowakowski, Associate Professor at UC San Francisco, on how the human genome builds neuronal cell types that support cognition and how this process goes awry in autism and schizophrenia.